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Abstract: Biomacromolecule-imprinted polymers with nanoscale sizes have received increased attention due to their potential applications in drug delivery, biomedical diagnostics and therapeutics [1,2]. Moreover, thermo-responsive affinity towards targeted biomacromolecules shows great advantages in controlled release, such as protein delivery. In this work, thermo-responsive molecularly imprinted spherical nanogels were easily prepared via redox initiated aqueous precipitation polymerization using lysozyme as template protein (Fig. 1). The diameters of the lysozyme imprinted (MIP) and non-imprinted (NIP) nanogels were around 110 nm and 160 nm, respectively. Furthermore, various sizes of lysozyme-imprinted nanogels from a few hundred to a few dozen nanometers could be synthesized simply by changing the amount of SDS during polymerization. Overall, the lysozyme imprinted nanogels demonstrated high binding capacity, rapid kinetic rebinding, excellent selectivity, and temperature-dependent adsorption towards lysozyme. In addition, such protein imprinted nanogels also showed temperature-dependent controlled release characteristics. Being able to precisely tune the particle size and thermo-responsive binding/releasing properties of template proteins, the present work provides a convenient yet versatile approach to prepare varisized biomolecule-imprinted nanogels for a broad spectrum of applications ranging from bioseparation and biosensors to drug delivery and therapeutics in vivo
Template and target information: protein, lysozyme
Author keywords: Molecularly imprinted nanogels, Thermo-responsive, protein recognition, controlled release, precipitation polymerization