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Abstract: Semiconductor nanocrystals, or quantum dots (QDs), with semiconducting and size-tunable optical properties, are very attractive for use in molecular and cellular imaging, optoelectronic devices, and biosensors and bioelectronics [1]. However, one of the major drawbacks of using QDs is the nonspecific binding to cellular membranes, proteins, and complex materials. The issue of nonspecific binding causes a high level of background fluorescence that limits tagging specificity and detection sensitivity, which will be a major barrier towards the widespread use of QDs. In this work, based on our previous work [2], we developed a general protocol for the fabrication of an imprinted matrix co-loaded with CdTe QDs and Fe3O4 nanoparticles for the recognition of p-nitrophenol, which is a widely used endocrine disrupting chemical (EDCs) (Scheme 1). The as-synthesized beads exhibited spherical shape (average size: 732 nm), high fluorescence intensity and superparamagnetic properties (Ms = 1.72 emu g-1). The hybrids bind the original template p-nitrophenol with an appreciable selectivity over structurally related compounds. This advancement of magnetic fluorescent imprinting technologies may lead to exciting developments in various fields, including environmental pollutants and biochemical detection, recognition elements in biosensors and biochips
Template and target information: p-nitrophenol