Inventors: Tang YW, Jin GY
Patent Title: Method for preparing benzodiazepine genus molecule surface print solid-phase extractant
Publication date: 2007
Publication number: CN101081360

Abstract: The process of preparing solid surface molecular engram extractant of benzodiazepine includes the following steps: dissolving benzodiazepine as molecular template in methanol, adding siloxane containing amino group as the functional monomer A and siloxane containing phenyl group as the functional monomer B via stirring to obtain pre-polymer solution, adding tetramethyl silane or tetraethyl silane via stirring, adding methylsulfonic acid activated silica gel particle, adding acid for hydrolytic condensation, filtering and drying to obtain coarse product, and final eluting to purify. The process is simple, and the prepared solid surface molecular engram extractant has selective target molecule identity, capability of eliminating impurity interference, high mechanical strength, stable physical and chemical properties, and small swelling factor.
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