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Inventors: Dong HX, Wang YH, Li JQ, Tong F, Wang ZX, Shen XD
Patent Title: Preparation method and application method of naphthidine molecularly-imprinted polymer
Publication date: 2012
Publication number: CN102311521

Abstract: The invention provides a preparation method and application method of a naphthidine molecularly-imprinted polymer. The preparation method provided by the invention comprises the following steps: dissolving S-1,1-binaphthyl-2-amine and methacrylic acid into a pore-forming agent, then feeding nitrogen for 5 minutes under an ultrasonic condition, and then carrying out pre-polymerization for 10 hours at the temperature of 18 DEG C and at normal pressure, so that the S-1,1-binaphthyl-2-amines and the methacrylic acid fully act so as to form a compound; adding ethylene glycol dimethacrylate and azo-bis-iso-butyrynitrile, and then feeding nitrogen for 5 minutes under the ultrasonic condition; placing the obtained product in a water bath kettle at the constant temperature of 60 DEG C to polymerize for 12 hours so as to obtain a bulk molecularly-imprinted polymer; crushing and grinding the obtained bulk molecularly-imprinted polymer; sieving with a sieve of 60mu m-20mu m meshes, and then carrying out repeated settlement with acetone to remove ultra-fine particles; and drying so as to obtain the naphthidine molecularly-imprinted polymer. As a HPLC (high performance liquid chromatography) stationary phase, the imprinted polymer can achieve the chiral separation of racemic DABN (1,1-binaphthyl-2-amine), and the separation factor of the imprinted polymer on the racemic DABN can reach 2.4. The preparation method provided by the invention is high in separation performance, low in cost, simple in operation, and good in stability.
URL: http://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120111&DB=EPODOC&locale=en_EP&CC=CN&NR=102311521A&KC=A&ND=4

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