Inventors: Lei JD, Ma GH, Su ZG, Kou X, Zhai YQ
Patent Title: Chloramphenicol molecular imprinting polymer microballoon with uniformity in size as well as preparation method and application thereof
Publication date: 2012
Publication number: CN102336871

Abstract: The invention discloses a chloramphenicol molecular imprinting polymer microballoon which has mean grain size of 1mum to 300mum and grain size distribution coefficient C.V of not more than 15 percent. The preparation method of the chloramphenicol molecular imprinting polymer microballoon comprises the following steps of: firstly, preparing emulsion by using a micro-fluidic device; secondly, curing the emulsion to obtain a molecular imprinting microballoon, wherein the micro-fluidic device comprises a plurality of micro channels; generating the emulsion when a dispersion phase is driven by an injection pump to enter a continuous phase from the micro channels; transferring the emulsion to another container and curing to obtain a polymer microballon; eluting the polymer microballon to remove a template molecule; and obtaining the molecular imprinting polymer microballoon. The dispersion phase contains the template molecule of chloramphenicol, a functional monomer, a cross linker, an evocating agent and a pore-foaming agent; and the continuous phase contains water and a dispersion agent. The invention also provides application of the chloramphenicol molecular imprinting microballoon.
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