Inventors: Xue W, Shi YF, Lv HL, Huang YX, Xie SS, Zhang Y, Ke Y
Patent Title: Method for preparing monodisperse molecularly imprinted polymer nano-microspheres
Publication date: 2012
Publication number: CN102432736

Abstract: The invention discloses a method for preparing monodisperse molecularly imprinted polymer nano-microspheres. The monodisperse molecularly imprinted polymer nano-microspheres are prepared by a precipitation polymerization method. The method comprises the following steps of: dispersing or dissolving a functional monomer, a crosslinking agent and template molecules in a liquid reaction medium, adding an initiator, and initiating polymerization reaction to obtain the monodisperse molecularly imprinted polymer nano-microspheres, wherein a synthetic antibacterial agent is taken as a template. In the method, the molecularly imprinted polymer nano-microspheres are prepared by uniquely combining molecular imprinting with the precipitation polymerization reaction, and the particle size and imprinting effect of a product, namely the microspheres are finely regulated and controlled by changing reaction conditions. By the method, regular microspheres which have smaller particle sizes, are uniformly dispersed and have intact structures can be prepared, the medicine loading capacity can be remarkably improved, and the sustained release can be realized; and the nano-microspheres are high in popularization and application value.
URL: http://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120502&DB=EPODOC&locale=en_EP&CC=CN&NR=102432736A&KC=A&ND=4