Inventors: Li H, Wan J, Gong GL, Wang XC
Patent Title: Preparation method of epothilone B molecularly imprinted polymer
Publication date: 2012
Publication number: CN102432753

Abstract: The invention discloses a preparation method of an epothilone B molecularly imprinted polymer and belongs to the technical field of chemical engineering. The preparation method comprises the following specific steps of: dissolving a template molecule (epothilone B), a functional monomer, a cross-linking agent and an initiator into a pore-foaming agent according to a certain mol ratio, wherein the pore-foaming agent can be a mixed solution of methanol and acetonitrile; after reaction, grinding and sieving the obtained product to obtain particles with the particle size being about 40-60mum; fully washing the obtained particles in a mixed solution of acetic acid and methanol according to the ratio being (1: 9)-(3:7) (v:v) so as to remove the template molecule; and freezing and drying to obtain the epothilone B molecularly imprinted polymer. The epothilone B molecularly imprinted polymer prepared by the preparation method disclosed by the invention can be used for specifically and selectively adsorbing the epothilone B and has greater application value in the production process of the epothilone B by adopting a liquid fermenting method.
URL: http://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120502&DB=EPODOC&locale=en_EP&CC=CN&NR=102432753A&KC=A&ND=4