Inventors: Sun XX, Sun CJ
Patent Title: Timolol maleate potentiometric chemical sensor and preparation method thereof
Publication date: 2009
Publication number: CN101556258

Abstract: The invention relates to and belongs to a potentiometric chemical sensor, in particular to a timolol maleate potentiometric chemical sensor and a preparation method thereof. The preparation method comprises the following steps: (1) carrying out the chemical modification by the periodic scanning electro-polymerization method after pre-processing the surface of the matrix electrode to prepare the chemically modified electrode; (2) preparing a PVC-film sensitive solution by the conventional method with the solvent being tetrahydrofuran, and coating the modified electrode with the PVC sensitive film by the dip-coating method to prepare a chemical sensor (I); (3) preparing the molecularly imprinted polymer (Polymer A) of timolol maleate, and preparing the PVC film (Film II) containing Polymer A; and (4) compounding the Film II onto the PVC sensitive film of the chemical sensor I.; The invention can effectively overcome the disadvantages of the existence of internal reference solution electrodes in the prior art, furthermore, the chemical sensor of the invention is significantly superior to the existing ion-selective electrodes in term of the selectivity of the drug (such as propranolol hydrochloride and the like) ions with the molecule with the structures, such as alcohol amine, imido and the like.
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