Inventors: Liu ZS, Huang YP, Li XY, Chen XX, Zhong DD
Patent Title: Molecularly imprinted monolithic column with high monomer content and preparation method
Publication date: 2015
Publication number: CN104258832

Abstract: The invention relates to a molecularly imprinted monolithic column with high monomer content and a preparation method. The molecularly imprinted monolithic column comprises the following materials in percent by weight: 1.96-3.82% of naproxen or ketoprofen, 2-5.22% of methyl methacrylate, 4.37-4.48% of 4-vinylpyridine, 0.32% of azodiisobutyronitrile, 67.8% of ethylene glycol dimethacrylate, 14.89-19.18% of 1-butyl-3-methylimidazole tetrafluoroborate and 2.56-6.54% of dimethyl sulfoxide. The molecularly imprinted monolithic column has the beneficial effects that by a formula design of a pore-forming agent, the content of monomers such as a functional monomer, a crosslinking agent and the like is up to 80%, and the content of the pore-forming agent is not more than 20%.; The ion liquid (1-butyl-3-methylimidazole tetrafluoroborate) is used as a main pore-forming agent, and the monolithic column with short synthesis time (shorter than 1.5 hours), specific imprinting effect and high column efficiency (N=11680platesm<-1>) is prepared. The molecularly imprinted monolithic column has the average diameter with the size from submicron to micron and is good in permeability. The molecularly imprinted monolithic column has the advantages that the environmental friendliness is better, the consumption of the pore-forming agent can be reduced by 2-3 times, the preparation method is simple and convenient, the permeability is good, the back pressure is low, the mechanical strength is good, and the molecular recognition effect is good.
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