Abstract: It is an urgent issue to extraction uranium (VI) from seawater for future long-term development of nuclear energy in the world. However, that still faces enormous challenges to selectively extract U(VI) from seawater. In this paper, a high selectivity surface U(VI)-imprinted graphitic carbon nitride/β-cyclodextrin composite sorbent were synthesized through a cross-linking method with U(VI) ions, β-cyclodextrin and epichlorohydrin as the template ion, the functional ligands and cross linking agent, respectively. The prepared ion-imprinted β-cyclodextrin modified graphitic carbon nitride polymer (IIP-g-C3N4/β-CD) were used for selective extraction of U(VI) from aqueous solution. Effects of different conditions were examined such as solution pH, oscillation time, temperature and so on. The results suggested that the IIP-g-C3N4/β-CD exhibits wonderful adsorption capacity and outstanding selectivity for U(VI) extraction under ppm level than nonimprinted material. The adsorption process closely correlates with the Langmuir adsorption isotherm model. At addition, the calculated maximum adsorption capacity was 859.66 mg g-1 at 25 °C, conforms the adsorption process belong to the monolayer chemisorption process. Accordingly, the IIP-g-C3N4/β-CD showed the excellent selective adsorption of U(VI) and cycle stability after five adsorption-desorption cycles with little adsorption capacity loss. Moreover, IIP-g-C3N4/β-CD exhibited outstanding U(VI) adsorption efficiency from simulated seawater indicting that IIP-g-C3N4/β-CD can be used a potential sorbent for efficiently selective adsorption of U(VI) from simulated seawater