Abstract: As a prospective ophthalmic drug delivery device, contact lenses attract a lot of attention due to the improved drug residence time and bioavailability. Herein, we proposed and fabricated a molecular imprinted structural color contact lens for sustained timolol release which could self-report the release process by color change. The specific recognition of target timolol by molecular imprinted sites can not only increased the loading amount and the residence time of the drug, but also endowed the structure color of lens remarkable blue shift with the accumulative release of timolol. The fascinating contact lens can be further used to controlling release a large number of ophthalmic drugs and has high potential to be a new generation of functional contact lenses