Abstract: The residues of amantadine and rimantadine in foods of animal origin are dangerous to the consumers. This study for the first time used adamantane as the dummy template to synthesize a molecularly imprinted polymer capable of simultaneous recognizing amantadine and rimantadine. The polymer was used as the recognition reagent to prepare a chemiluminescence sensor on the conventional 96-well microtiter plate for determination of the two drugs in chicken and pork samples. Results showed that one test could be finished within 20 min, and the sensor could be reused for 6 times. Due to the 4-(imidazol-1-yl)phenol enhanced luminol-H2O2 signal system, the limit of detection for the two analytes was 1.0 pg mL-1. The recoveries of the two analytes from the standards fortified blank meat samples were in the range of 67.2%-93.5%. Therefore, the sensor could be used as a simple, rapid, sensitive, specific and recyclable tool for routine monitoring the residues of amantadine and rimantadine in meat