Abstract: At the present study, we have reported a new sensor based on immobilized molecularly imprinted polymer on the surface of a glassy carbon electrode (GCE) through electro polymerization of o-Dihydroxybenzene (o-DB) and o-phenylenediamine (o-PD) as monomers for direct determination of repaglinide (RPG) as target molecule. RPG is a new generation of oral anti-diabetic drugs that has a rapid onset of action and short half-life of approximately 1 h. So developing a controlled system with good sensitivity and selectivity is required to eliminate its adverse effects. Under the optimized conditions, the proposed sensor showed a good selectivity to detect RPG among compounds with similar structure and properties with RPG. The linear range for analysis were 0.005-1.0 μM and detection limit 1.8 nM was achieved. Furthermore, the experimental results showed that the proposed sensor was highly selective and sensitive to detect RPG in real samples such as blood serum, urine and RPG tablet
Author keywords: Repaglinide, Molecularly imprinted polymer, Electropolymerization