MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Reference type: Journal
Authors: Zhang SZ, Zhao Y
Article Title: Tuning surface-cross-linking of molecularly imprinted cross-linked micelles for molecular recognition in water.
Publication date: 2018
Journal: Journal of Molecular Recognition
Page numbers: e2769.
DOI: 10.1002/jmr.2769

Abstract: Molecular recognition in water is an important challenge in supramolecular chemistry. Surface-core double cross-linking of template-containing surfactant micelles by the click reaction and free radical polymerization yields molecularly imprinted nanoparticles (MINPs) with guest-complementary binding sites. An important property of MINP-based receptors is the surface-cross-linking between the propargyl groups of the surfactants and a diazide cross-linker. Decreasing the number of carbons in between the two azides enhanced the binding affinity of the MINPs, possibly by keeping the imprinted binding site more open prior to the guest binding. The depth of the binding pocket can be controlled by the distribution of the hydrophilic/hydrophobic groups of the template and was found to influence the binding in addition to electrostatic interactions between oppositely charged MINPs and guests. Cross-linkers with an alkoxyamine group enabled two-stage double surface-cross-linking that strengthened the binding constants by an order of magnitude, possibly by expanding the binding pocket of the MINP into the polar region. The binding selectivity among very similar isomeric structures also improved
Author keywords: binding, cross-linking, hydrophobic interactions, Micelle, Molecular imprinting, Nanoparticle, water soluble

  Double Bonds spoof movie poster mug  Chemistry peptide mug  Chemists are fun customisable shirt

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner