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Abstract: A novel molecularly imprinted electrochemical sensor was constructed for the determination of lidocaine, which has a porous and three-dimensional nanostructure. Firstly, dendritic Pt-Pd bimetallic nanoparticles (NPs) and porous Pt nano-networks (NWs) were prepared using hexadecylpyridinium chloride as a structure-directing agent. Then, the dendritic Pt-Pd NPs were embedded onto porous Pt NWs and the resultant mixture was coated on a carboxyl graphene modified glassy carbon electrode. Afterwards, the suspension of aminated multi-walled carbon nanotubes loaded with dendritic Pt-Pd NPs was dropped onto the modified electrode surface to reinforce such porous NW and enlarge electrode surface area. Subsequently, a molecularly imprinted polymer film was fabricated by cyclic voltammetry at the modified electrode, using lidocaine as the template and o-phenylenediamine as the monomer. Under optimal conditions, the obtained electrochemical sensor offered an excellent response for lidocaine, the linear response range was from 5.0 x 10-9 to 4.8 x 10-6 mol L-1 and the detection limit was 1.0 x 10-10 mol L-1. It was successfully applied to the detection of lidocaine in real samples with satisfactory results
Template and target information: lidocaine