MIPdatabase
Authors: Wang JF, Zhou LM, Liu XL, Wang QH, Zhu DQ
Article Title: Novel polymer system for molecular imprinting polymer against amino acid derivatives.
Publication date: 2000
Journal: Chinese Journal of Chemistry
Volume: 18
Issue: (4)
Page numbers: 621-625.
DOI: 10.1002/cjoc.20000180432
Alternative URL: http://sioc-journal.cn/chub/18040621.pdf
Abstract: Molecular imprinting polymers (MIPs) against N-Cbz-L-Tyr were prepared utilizing different polymer systems and evaluated in HPLC mode. It was found that MIP utilizing cocktail functional monomers, acrylamide + 2-vinylpyridine showed better molecular recognition and better separation ability for the template molecule than those utilizing other functional monomers. MIP utilizing trimethylolpropane trimethacrylate as cross-linker showed higher load capacity and separation factor than those utilizing ethylene glycol dimethacrylate as cross-linker. Increasing the concentration of competing solvent, acetic acid weakened the ionic inter-action and hydrogen bonding between the analyte and the functional monomers, 2-vinylpyridine and acrylamide, when the template enantiomer was separated by HPLC. Therefore increasing of the concentration of acetic acid leads to decreasing of capacity factor, separation factor and resolution
Template and target information: N-Cbz-L-Tyr
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