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Editors: Takahashi M
Publisher: World Scientific Publ. Co. Pte. Ltd.
City: Singapore
ISBN: 978-981-4719-81-0; 978-981-4719-80-3
Conference information: Proceedings of the 2015 International Conference on Medicine and Biopharmaceuticals

Abstract: In this paper, a novel analysis method for detecting codeine using a combination of molecular imprinting technology (MIT) and surface plasmon resonance (SPR) technique was established. Since no reports concerning this subject have been published, this innovative study was conducted as a trial. The following conditions were implemented in the synthesis of the imprinting membrane: codeine was used as the template molecule, methacrylic acid (MAA) was used as the functional monomer, ethylene glycol dimethyl acrylic ester (EGDMA) was used as the cross-linking agent, azobisisobutyronitrile (AIBN) was used as the initiating agent, and acetonitrile was used as the solvent. The effective ratio of the template, monomer, and cross-linking agent was equal to codeine: MAA:EGDMA=1:4:8. A complete, homogenous, and stable codeine molecular imprinting polymer membrane was successfully prepared on the surface of the golden chips after a 12-hour reaction time at a 65 degrees C controlling temperature. Moreover, the results of the absorption elution test conducted on the codeine molecular imprinting polymer membrane suggested that the absorption concentration was linear with a regression equation equal to y=-0.315x+3.455 (R2=0.9878) and a resonance angle within 10(-15) similar to 10(-8) mol/L. According to these results, the attenuated codeine concentration could be deduced and applied in the quantitative determination of codeine.
Template and target information: codeine