MIPs logo MIPdatabase      MIP2018 Conference website
Custom Search
Reference type: Journal
Authors: Stilman W, Jooken S, Wackers G, Cornelis P, Khorshid M, Yongabi D, Akkermans O, Dyson S, Van Grinsven B, Cleij T, van Ijzendoorn L, Wagner P, Eersels K
Article Title: Optimization and characterization of a flow cell for heat-transfer-based biosensing.
Publication date: 2017
Journal: physica status solidi (a)
Volume: 214
Issue: (9)
Page numbers: ArticleNo1600758.
DOI: 10.1002/pssa.201600758

Abstract: In this article, we report on the development of a flow cell optimized for the heat-transfer method, a versatile biosensing technique. The design of the flow cell ensures that the heat flow is focused with minimal heat loss through the surroundings of the cell. This results in a more stable measuring signal and an improved sensitivity of the measuring technique. The sensor was characterized by performing background measurements in air, water, and phosphate buffered saline (PBS) solution. Heat flow through the setup was simulated using COMSOL in order to provide insight in the contribution of convection to the heat flow and recommendations for possible future improvements to the cell. Additionally, a two-step algorithm for calculating thermal resistance was defined, allowing the user to accurately derive thermal conductivity from experimental data. Finally, the potential of the flow cell for bacteria (Escherichia coli) detection was assessed and compared with the results obtained in the original HTM setup in a similar experiment. This experiment demonstrates that we were able to improve the limit-of-detection (LoD) to 2.10 x 10^4 colony forming units (CFU) mL-1 by changing the geometry of the measuring cell. Sensor setup for thermal biodetection experiments a directed heat flow
Template and target information: Escherichia coli, E.coli, bacteria
Author keywords: bacteria, Biosensors, COMSOL simulations, heat transfer, interfaces, thermal resistance


  Meitnerium periodic table mug  Mug featuring the name Patrick spelled out in the single letter amino acid code  I shop perodically customisable tote bag

Molecules Special Issue call






Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:
US listings   UK listings

Searching for Molecular Imprinting books on Amazon.com:
Molecular Imprinting
Imprinted Polymers
Polymer Chemistry
Organic Chemistry
Biosensors

Find what you need at Amazon.com

Lab supplies from Amazon