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Abstract: The performance of MIP is related with the thermodynamic stability of the pre-polymerization complex. The stability of pre-polymerization complex is influenced by functional monomer, cross-linker, and porogen. These factors in conjugation with the microenvironment polarity determine the binding behaviours of MIP. Methylphosphonic acid (MPA), the ultimate degradation product and persistent environmental marker of nerve agents, was selected as target. In present work, 31P{1H}NMR was employed to optimize imprinting conditions of derivative of MPA. This approach comprised of screening of functional monomer, cross-linker, porogen and stability of pre-polymerization complex before and during polymerization and the MIP was synthesized accordingly. Sorption properties of MIP were elucidated by batch rebinding studies. The selectivity of MIP towards the template was confirmed by comparing its binding with structural analogues of phosphonate esters. These results indicate that 31P{1H}NMR is a simple and effective method for the rational design of MIP for phosphorus containing environmental contaminants
Template and target information: methylphosphonic acid, MPA
Author keywords: molecularly imprinted polymer (MIP), Template-monomer pre-polymerization complex stability, 31P{1H}NMR analysis, Nerve agents marker