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Reference type: Journal
Authors: Sun CH, Wang JH, Huang JJ, Yao DD, Wang CZ, Zhang L, Hou SY, Chen LN, Yuan CS
Article Title: The Multi-Template Molecularly Imprinted Polymer Based on SBA-15 for Selective Separation and Determination of Panax notoginseng Saponins Simultaneously in Biological Samples.
Publication date: 2017
Journal: Polymers
Volume: 9
Issue: (12)
Page numbers: ArticleNo653.
DOI: 10.3390/polym9120653
Alternative URL: http://www.mdpi.com/2073-4360/9/12/653

Abstract: The feasible, reliable and selective multi-template molecularly imprinted polymers (MT-MIPs) based on SBA-15 (SBA-15@MT-MIPs) for the selective separation and determination of the trace level of ginsenoside Rb1 (Rb1), ginsenoside Rg1 (Rg1) and notoginsenoside R1 (R1) simultaneously from biological samples were developed. The polymers were constructed by SBA-15 as support, Rb1, Rg1, R1 as multi-template, acrylamide (AM) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as cross-linker. The new synthetic SBA-15@MT-MIPs were satisfactorily applied to solid-phase extraction (SPE) coupled with high performance liquid chromatography (HPLC) for the separation and determination of trace Rb1, Rg1 and R1 in plasma samples. Under the optimized conditions, the limits of detection (LODs) and quantitation (LOQs) of the proposed method for Rb1, Rg1 and R1 were in the range of 0.63-0.75 ng mL-1 and 2.1-2.5 ng mL-1, respectively. The recoveries of R1, Rb1 and Rg1 were obtained between 93.4% and 104.3% with relative standard deviations (RSDs) in the range of 3.3-4.2%. All results show that the obtained SBA-15@MT-MIPs could be a promising prospect for the practical application in the selective separation and enrichment of trace Panax notoginseng saponins (PNS) in the biological samples
Template and target information: multi-template, ginsenoside Rb1, Rb1, ginsenoside Rg1, Rg1, notoginsenoside R1, R1
Author keywords: multi-template molecularly imprinted polymers, SBA-15, Panax notoginseng saponins, separation and determination, Solid-phase extraction

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