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Volume number: Proceedings of the 31st Congress on Science and Technology of Thailand at Suranaree University of Technology

Abstract: Molecularly imprinted polymer microspheres were prepared by precipitation polymerization using a sacrificial covalent bond. In the present model cholesteryl (4-vinyl) phenyl carbonate was used as a template monomer. The imprinted microspheres were prepared using ethylene glycol dimethacrylate (EDMA) and divinylbenzene (DVB) as cross-linker. The base-labile carbonate ester bond was easily hydrolyzed to leave imprinted cavities in the resulting polymers. Radioligand binding analysis, elemental analysis and scanning electron microscopy were used to characterize the imprinted materials. Imprinted microspheres prepared from DVB cross-linker had larger and more defined spherical shape, and displayed better imprinting effect than EDMA-based microparticles. For comparison, imprinted bulk polymers were also prepared in the same reaction solvent as that used in precipitation polymerization. Results indicated that imprinted microspheres contained more template monomer units than bulk materials. Efficiency of template removal by hydrolysis treatment for microspheres was higher than for bulk polymers. For DVB-based polymers, imprinted microspheres displayed higher specific cholesterol uptake than the corresponding bulk polymer.
Template and target information: cholesterol, cholesteryl (4-vinyl) phenyl carbonate