MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Duan ZJ, Fan LP, Fang GZ, Yi JH, Wang S
Article Title: Novel surface molecularly imprinted sol-gel polymer applied to the online solid phase extraction of methyl-3-quinoxaline-2-carboxylic acid and quinoxaline-2-carboxylic acid from pork muscle.
Publication date: 2011
Journal: Analytical and Bioanalytical Chemistry
Volume: 401
Issue: (7)
Page numbers: 2291-2299.
DOI: 10.1007/s00216-011-5329-0

Abstract: A new molecularly imprinted polymer (MIP), selective for major metabolites of quinoxaline-1,4-dioxides was firstly prepared by combining surface molecular imprinting technique with the sol-gel process. Methyl-3-quinoxaline-2-carboxylic acid (MQCA) was used as template, 3-aminopropyltriethoxysilane as functional monomer, and tetraethoxysilicane as cross-linker. The MIP was characterized by Fourier transform infrared and evaluated through static adsorption experiments. The results indicated that MIP had high adsorption capacity, fast binding kinetics for MQCA, and the polymer showed a high degree of cross-reactivity for quinoxaline-2-carboxylic acid (QCA). The MIP was then applied as a selective sorbent in an online solid phase extraction (SPE) coupled with high-performance liquid chromatography (HPLC). For a 50-mL sample solution, enrichment factors of 1,349 and 1,046 for QCA and MQCA, respectively, and limits of detection (S/N = 3) of 0.8 and 2 ng L -1 for QCA and MQCA, respectively, were obtained (corresponding to 0.02 and 0.04 ng g -1 in solid samples for final 100 mL of sample solutions of 5 g of pork). The sample preparation protocol was simplified and only included one step extraction with acetonitrile (MeCN) after the release of target analytes through acidic hydrolysis without further sample cleanup. The new MIP-SPE-HPLC method was successfully applied to the quantification of trace QCA and MQCA in pork muscle with good recoveries ranging from 67% to 80% and RSD below 8%. Figure A new molecularly imprinted polymer (MIP), selective for methyl-3-quinoxaline-2-carboxylic acid (MQCA) and quinoxaline-2-carboxylic acid (QCA), was prepared by combining surface molecular imprinting technique with the sol-gel process. The MIP could be applied as a selective sorbent of an online solid phase extraction (SPE) coupled with high-performance liquid chromatography (HPLC)
Template and target information: methyl-3-quinoxaline-2-carboxylic acid, MQCA, quinoxaline-2-carboxylic acid, QCA
Author keywords: Quinoxaline-2-carboxylic acid, Methyl-3-quinoxaline-2-carboxylic acid, molecularly imprinted polymer, sol-gel, Online solid phase extraction, Pork


  Mister Benzene Birthday card  Chemistry peptide mug  Beach bunny periodic table shirt

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner