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Reference type: Journal
Authors: Li LF, Liang YZ, Liu YC
Article Title: Designing of molecularly imprinted polymer-based potentiometric sensor for the determination of heparin.
Publication date: 2013
Journal: Analytical Biochemistry
Volume: 434
Issue: (2)
Page numbers: 242-246.
DOI: 10.1016/j.ab.2012.12.007
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0003269712006264

Abstract: A novel potentiometric sensor with high selectivity and sensitivity has been developed for the determination of heparin, based on the modification of heparin-imprinted polymer film onto a glassy carbon. The performance of the developed heparin sensor was evaluated, and the results indicated that a sensitive potentiometric sensor could be fabricated. The obtained heparin sensor shows high-selectivity monitoring of heparin, shorter response time (< 4 min), wider linear range (0.003 - 0.7 μM), lower detection limit (0.001 μM), and satisfactory long-term stability (> 2 months). The potentiometric sensor was successfully applied to the determination of heparin in heparin sodium injection with recoveries between 97.1% and 110.0%
Template and target information: heparin
Author keywords: Heparin, potentiometric sensor, molecularly imprinted polymer (MIP), Glassy carbon, detection


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