Abstract: A novel potentiometric sensor with high selectivity and sensitivity has been developed for the determination of heparin, based on the modification of heparin-imprinted polymer film onto a glassy carbon. The performance of the developed heparin sensor was evaluated, and the results indicated that a sensitive potentiometric sensor could be fabricated. The obtained heparin sensor shows high-selectivity monitoring of heparin, shorter response time (< 4 min), wider linear range (0.003 - 0.7 μM), lower detection limit (0.001 μM), and satisfactory long-term stability (> 2 months). The potentiometric sensor was successfully applied to the determination of heparin in heparin sodium injection with recoveries between 97.1% and 110.0%
Template and target information: heparin
Author keywords: Heparin, potentiometric sensor, molecularly imprinted polymer (MIP), Glassy carbon, detection