Abstract: Glycylglycine imprinted polymer microspheres (Gly-Gly-MIPMs) were synthesized by emulsion polymerization using glycylglycine as template, acrylamide as monomer and ethylene glycol dimethacrylate as crosslinker. The preparation conditions on the water phase morphology and size distributions of the influence and the polymer microspheres adsorption properties were discussed. The optimum preparation conditions were: mass ratio of emulsifier Tween-80 to Span-80 3:1, amount of 5% of monomer, initiator dosage of 1.1% monomer, reaction temperature 45 °C, and stirring speed 450 r/min. Gly-Gly-MIPMs were monodisperse, with an average diameter of about 100 nm, imprinted polymers on two-Gly peptides showed better specific adsorption, which contained two different kinds of binding sites, and their imprinting factor was up to 2.18
Template and target information: glycylglycine, Gly-Gly
Author keywords: emulsion polymerization, Glycylglycine, molecular imprinting, Polymeric microspheres

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