Abstract: A liquid chromatography-mass spectrometry (LC-MS) method for the analysis of β-agonists in bovine muscle is developed. Sample clean-up is based on molecular imprinted polymers (MIPs). The LC-MS method was validated for screening purposes. The validation results show that eight compounds (cimaterol, cimbuterol, ractopamine, clenproperol, clenbuterol, brombuterol, mabuterol, mapenterol and isoxsuprine) meet the requirements for quantitative determination using MIPs for sample clean-up. Reliable screening is possible as low as 1 μg kg-1. The method was validated for bovine muscle but also has proven to be suitable for muscle samples from rabbit, duck and turkey, liver and various kinds of fish
Template and target information: cimaterol, cimbuterol, ractopamine, clenproperol, clenbuterol, brombuterol, mabuterol, mapenterol, isoxsuprine
Author keywords: molecular imprinted polymer, beta-agonists, Growth promoter, residues, muscle

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