Abstract: A new restricted access materials combined to molecularly imprinted polymers (RAM-MIP) with hydrophilic external layer were prepared and their applicability in p-acetaminophenol (AMP) selective recognition and release was evaluated. Glycidilmethacrylate (GMA) was used as pro-hydrophilic co-monomer, and GMA epoxide ring opening with perchloric acid was performed for the hydrophilic modification of polymeric surface. Morphological and hydrophilic properties by scanning electron microscopy and water content measurement were determined and recognition and selectivity properties of RAM-MIP were compared to the unmodified MIP. With RAM-MIP, both hydrophobic non-specific interactions between template or its analogues and polymeric matrices, and bovine serum albumin absorption were drastically reduced
Template and target information: p-acetaminophenol, AMP, paracetamol
Author keywords: Molecularly imprinted polymers, Restricted access materials, surface modification, Epoxide ring opening

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