Abstract: A novel paracetamol electrochemical sensor based on molecular imprinted polymer has been developed.The sensitive layer was prepared by electropolymerization of o-phenylenediamine on a glassy carbon electrode in the presence of the template(paracetamol)which can be removed by ethanol.Square wave voltammetry was applied to investigate the analytical characteristics of the sensor,and indirect analytical method based on the medium of K3[Fe(CN)6]was established.The sensor shows great promise for specific,and sensitive detection of paracetamol.This sensor provided a linear range from 2.0×10-6 to 8.0×10-5mol/L and a detection limit of 2.0×10-8 mol/L.The proposed method was applied to determination of paracetamol in different tablets and the obtained results were satisfactory.
Template and target information: paracetamol, acetaminophen
Author keywords: paracetamol, molecular imprinted polymer, electrochemical polymerization of o-phenylenediamine, sensor

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