Abstract: A sensitive method for the determination of chloramphenicol(CAP) in milk was developed based on its strong electrochemiluminescence(ECL) inhibition of Ru(bpy)32+/TPA system,combined with molecularly imprinted solid phase extraction(MISPE).Under the optimized conditions,the quenched ECL intensity versus the logarithm of the concentration of CAP was linear over a concentration range from 1.0 × 10-13 to 1.0 × 10-11 g/mL,and the limit of detection(LOD) was found to be 3 × 10-12 g/mL.The precision and accuracy were good.This method was successfully applied to determination of the trace CAP residue in milk.
Template and target information: chloramphenicol, CAP
Author keywords: Electrochemiluminescence (ECL), Molecularly imprinted solid phase extraction (MISPE), Chloramphenicol (CAP), Ru(bpy)32+, milk

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