Abstract: Building blocks for a bright future: A new method for the synthesis of organic nanoparticles (NPs) was developed combining a molecularly imprinted polymer shell and a fluorescent dendrimer biosensing core. Cubic organic nanoparticles are reported for the first time. The polymeric nanoparticles could be used as a direct replacement for antibodies in biosensor applications. Template and target information:acetoguanamine, melamine Author keywords:Biosensors, Core-shell structures, dansyl group, living polymerization, surface plasmon resonance