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Reference type: Journal
Authors: balamurugan K, Gokulakrishnan K, Prakasam T
Article Title: Preparation and Evaluation of Molecularly Imprinted Polymer liquid Chromatography Column for the separation of Ephedrine Enantiomers.
Publication date: 2015
Journal: Arabian Journal of Chemistry
Volume: In Press, Corrected Proof
DOI: 10.1016/j.arabjc.2011.06.024

Abstract: In this study molecular imprinting technology was employed to prepare a specific affinity sorbent for the resolution of Ephedrine, a chiral drug. The molecularly imprinted polymer (MIP) was prepared by non-covalent molecular imprinting with either (+) or (-)-Ephedrine ((R*,S*)-2-(methylamino)-1-phenylpropan-1-ol) as the template. Methacrylic acid and ethylene glycol di-methacrylate were copolymerized in the presence of the template molecule. The bulk polymerization was carried out in chloroform with 2,2'-azobisisobutyronitrile as the initiator, at 5 C and under UV radiation. The resulting MIP was ground into powders, which were slurry packed into analytical columns. After removal of template molecules, the MIP-packed columns were found to be effective for the resolution of ()-Ephedrine racemates. The separation factor for the enantiomers ranged between 1.3 and 2.1 when the column was packed with MIP prepared with (+)-Ephedrine as the template. A separation factor ranging from 1.3 to 2.6 could be achieved from the column packed with MIP, prepared with (-)-Ephedrine as the template. Although the separation factor was higher with that previously obtained from reversed-phase column chromatography following derivatization with a chiral agent, elution peaks were broader due to the heterogeneity of binding sites on MIP particles and the possible non-specific interaction
Author keywords: Enantiomers, Ephedrine, Chiral drug, Molecularly imprinted polymers, Template

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