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Reference type: Journal
Authors: Maouche N, Ktari N, Bakas I, Fourati N, Zerrouki C, Seydou M, Maurel F, Chehimi MM
Article Title: A surface acoustic wave sensor functionalized with a polypyrrole molecularly imprinted polymer for selective dopamine detection.
Publication date: 2015
Journal: Journal of Molecular Recognition
Page numbers: n/a.
DOI: 10.1002/jmr.2482

Abstract: A surface acoustic wave sensor operating at 104 MHz and functionalized with a polypyrrole molecularly imprinted polymer has been designed for selective detection of dopamine (DA). Optimization of pyrrole/DA ratio, polymerization and immersion times permitted to obtain a highly selective sensor, which has a sensitivity of 0.55/mM ( 550 Hz/mM) and a detection limit of 10 nM. Morphology and related roughness parameters of molecularly imprinted polymer surfaces, before and after extraction of DA, as well as that of the non imprinted polymer were characterized by atomic force microscopy. The developed chemosensor selectively recognized dopamine over the structurally similar compound 4-hydroxyphenethylamine (referred as tyramine), or ascorbic acid,which co-exists with DA in body fluids at a much higher concentration. Selectivity tests were also carried out with dihydroxybenzene, for which an unexpected phase variation of order of 75% of the DA one was observed. Quantum chemical calculations, based on the density functional theory, were carried out to determine the nature of interactions between each analyte and the PPy matrix and the DA imprinted PPy polypyrrole sensing layer in order to account for the important phase variation observed during dihydroxybenzene injection. Copyright 2015 John Wiley & Sons, Ltd
Author keywords: surface acoustic wave (SAW) sensor, Molecularly imprinted polymer (MIP), dopamine, atomic force microscopy (AFM), DFT calculations

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