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Reference type: Journal
Authors: Giovannoli C, Passini C, Anfossi L, Di Nardo F, Spano G, Maurino V, Baggiani C
Article Title: Comparison of binding behavior for molecularly imprinted polymers prepared by hierarchical imprinting or Pickering emulsion polymerization.
Publication date: 2015
Journal: Journal of Separation Science
Page numbers: n/a.
DOI: 10.1002/jssc.201500511

Abstract: The aim of this study was the evaluation of the binding performances and selectivity of molecularly imprinted beads prepared towards several penicillins (i) by hierarchical bulk polymerization in the pores of template-grafted silica microbeads (hMIPs) and (ii) by Pickering emulsion polymerization in the presence of template-decorated silica nanobeads (pMIPs). 6-Aminopenicillanic acid was chosen as common fragmental mimic template. Both approaches produced micron-sized polymeric beads with good recognition properties towards the target ligands whereas the selectivity pattern appeared quite different. The polymer prepared by the Pickering emulsion approach showed binding properties similar to imprinted beads prepared by hierarchical approach. Equilibrium binding constants changed their values from 0.1-0.2 x 10^6 M-1 (hMIPs) to 0.2-0.6 x 10^6 M-1 (pMIPs), while the binding site densities changed from 3.7-4.8 μmol/g (hMIPs) to 0.3-0.55 μmol/g (pMIPs). Compared to the hierarchical polymerization, Pickering emulsion polymerization represents a more practical approach when a template mimic needs to be used. This article is protected by copyright. All rights reserved
Author keywords: Hierarchical imprinting, mimic template, Molecular imprinting, Pickering emulsion, Penicillins

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