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Reference type: Journal
Authors: Xue C, Wang X, Zhu WY, Han Q, Zhu CH, Hong JL, Zhou XM, Jiang HJ
Article Title: Electrochemical serotonin sensing interface based on double-layered membrane of reduced graphene oxide/polyaniline nanocomposites and molecularly imprinted polymers embedded with gold nanoparticles.
Publication date: 2014
Journal: Sensors and Actuators B: Chemical
Volume: 196
Page numbers: 57-63.
DOI: 10.1016/j.snb.2014.01.100
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0925400514001257

Abstract: A double-layered membrane sensing interface was fabricated for sensitive and selective detection of serotonin (5-hydroxytryptamine, 5-HT) based on reduced graphene oxide (rGO)/polyaniline (PANI) nanocomposites and molecularly imprinted polymers (MIPs) embedded with gold nanoparticles (AuNPs). rGO/PANI nanocomposites were synthesized via electro-deposition process, in which protonated anilines were first anchored on the rGO sheets through electrostatic adsorption, and then the rGO/PANI membrane was formed on the bare electrode via cyclic voltammetry method. Functionalized AuNPs (F-AuNPs) were prepared to fabricate the MIPs embedded with AuNPs (AuNPs@MIPs) membrane on the modified electrode by constant potential method in the presence of 5-HT and p-aminothiophenol. The materials prepared in this work were examined by ultraviolet-visible (UV-Vis) and Raman spectroscopy, and the as-prepared membranes were characterized by scanning electron microscope, energy dispersive spectroscopy, and electrochemical methods. In addition, the obtained sensor allowed remarkable selectivity to 5-HT against the interferences caused by ascorbic acid and other interferents. A linear dependence of peak current in differential pulse voltammograms was obtained over 0.2-10.0 μmol L-1 5-HT with the limit of detection of 11.7 nmol L-1 (S/N = 3). Furthermore, the obtained biomimetic sensor was employed to detect 5-HT in human serum samples
Template and target information: serotonin, 5-hydroxytryptamine, 5-HT
Author keywords: Serotonin, Functionalized gold nanoparticles, Embedded gold nanoparticles, Molecularly imprinted polymers, Electrochemical sensor

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