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Reference type: Journal
Authors: Guo ZN, Chen L, Lv HM, Yu Z, Zhao B
Article Title: Magnetic imprinted surface enhanced Raman scattering (MI-SERS) based ultrasensitive detection of ciprofloxacin from a mixed sample.
Publication date: 2014
Journal: Analytical Methods
Volume: 6
Issue: (6)
Page numbers: 1627-1632.
DOI: 10.1039/C3AY40866C

Abstract: A new method for fast extraction and ultra-sensitive detection of ciprofloxacin based on magnetic imprinted surface-enhanced Raman scattering (MI-SERS) has been developed in this paper. This method is a combination of three techniques, which are a magnetic separation technique, a molecular imprinting technique and a surface-enhanced Raman scattering technique. We designed and fabricated core-shell structured magnetic molecularly imprinted polymers (MIPs) which can be applied to specifically recognise ciprofloxacin and extract it from a mixed system. The whole extraction and clean-up procedures are assisted by a magnetic field, which makes it much easier than traditional centrifugal separation. In addition to this, surface-enhanced Raman scattering (SERS) was applied as the detection tool, which makes the detection limit for ciprofloxacin by this method as low as 10-9 mol L-1. Furthermore, we integrated these core-shelled magnetic-MIPs on a magnet chip and detected ciprofloxacin from fetal bovine serum. The whole detection process can be finished within ten minutes and the limit of detection by this chip can reach 10-7 mol L-1
Template and target information: ciprofloxacin

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