Abstract: Progesterone imprinted copolymer membranes of acrylonitrile with acrylic acid, methacrylic acid and acrylamide were synthesised by phase inversion technique. The developed membranes were characterised by FT-IR and SEM techniques. Imprinted membranes showed specificity towards the template progesterone. Among the various copolymers, the acrylamide incorporated copolymer showed high binding towards the used template. Investigation of the selectivity characteristics revealed that the developed membranes showed selectivity toward the template progesterone than similar compounds. The bound template could be totally recovered and regenerated membranes maintain their recognition property after repeated use. On the basis of the results, the imprinted polymer can be applied for the direct extraction of progesterone in clinical analysis.
Template and target information: progesterone
Author keywords: molecular imprinting, Acrylic copolymers, membranes, Progesterone, binding capacity, Urine analysis