MIPs logo MIPdatabase    HoHoHo MIP2018 Conference website
Custom Search
Reference type: Journal
Authors: Najafizadeh P, Ebrahimi SA, Panjeshahin MR, Hesari KK, Rezayat Sorkhabadi SM
Article Title: Synthesis of a phenylalanine imprinted polymer for attenuation of phenylalanine absorption via the gut in a murine hyperphenylalaninemia model.
Publication date: 2014
Journal: Journal of Materials Chemistry B
Volume: 2
Issue: (15)
Page numbers: 2144-2152.
DOI: 10.1039/C3TB21826K

Abstract: Polymer technology plays an influential role in biomedical sciences. Molecular imprinting is a technique for preparation of polymers with structure-selective adsorptive properties. High selectivities of these materials have nowadays advanced to the point that they are being utilized for several biomedical applications such as drug delivery. Phenylketonuria is a genetic disease characterized by accumulation of phenylalanine (Phe) in blood with toxic consequences. The aim of the present study is to synthesize a phenylalanine imprinted polymer for attenuation of phenylalanine absorption in the gut in a murine hyperphenylalaninemia model. A molecularly imprinted polymer (MIP) against Phe and a non-imprinted polymer (NIP) were synthesized and their Phe binding properties were studied in Simulated Intestinal Fluid (SIF). Two classes of binding sites were then found in the MIP: high affinity (KD = 62.5 μM) and low affinity (KD = 1 mM). Histological toxicity and LD50 of the MIP, after oral administration to murine hyperphenylalaninemia, were examined prior to investigation of the effects of the imprinted polymer on blood Phe concentrations in animal models. Our findings suggest that the MIP against Phe can decrease the blood Phe concentration in an animal model of hyperphenylalaninemia
Template and target information: phenylalanine, Phe


  SMI logo mouse mat  Periodic table Genius shirt  Lab Chick script shirt

Molecules Special Issue call     Sensors Special Issue call






Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:
US listings   UK listings

Searching for Molecular Imprinting books on Amazon.com:
Molecular Imprinting
Imprinted Polymers
Polymer Chemistry
Organic Chemistry
Biosensors

Find what you need at Amazon.com

Lab supplies from Amazon