MIPs logo MIPdatabase      MIP2024 Conference banner, website is now open, register on site for important updates   
Custom Search
Reference type: Journal
Authors: Hou LT, Chen JJ, Fu HJ, Xue J, Cheng LW
Article Title: Preparation of L-Carnitine Molecularly Imprinted Polymers and Recognition Charateristics.
Publication date: 2014
Journal: Acta Polymerica Sinica
Issue: (3)
Page numbers: 385-392.
DOI: 10.3724/SP.J.1105.2014.13268
Alternative URL: http://www.gfzxb.org/EN/abstract/abstract14064.shtml

Abstract: A molecularly imprinted polymer (MIP) with specific molecule identification properties for L-carnitine was synthesized on the surface of modified silica, using L-carnitine as template molecule, ethyleneglycol dimethacrylant (EGDMA) as the cross-linker, methacrylic acid (MAA) as functional monomer and 2,2'-azobisisobutyronitrile (AIBN) as the initiator respectively. The binding effect of the complex formed between the template and the functional monomer were obtained by UV spectrophotometry. The MIP was characterized by IR spectroscopy and SEM, and the results demonstrated the formation of a grafted polymer layer on the modified silica gel surface.The absorption kinetics experiments indicated that compared with non-imprinted polymer, MIP showed better recognition ability and absorptivity. Moreover, the polymer was investigated in static adsorption equilibrium experiments and the Scatchard analysis to evaluate the adsorption characteristics. The results showed that the homogeneous binding sites were formed in the MIP, and the dissociation constants (Kd) and the apparent maximum number (Qmax) of binding sites were estimated to be 2.76 x 10-4 mol/L and 71.00 μmol/g, respectively.The selective binding experiment for substrates shows that the affinity and selectivity of the MIP for L-carnitine are higher than those for D-carnitine and two other different substrates. MIP also showed good selectivity for L-carnitine through the resolution experiments.
Template and target information: L-carnitine
Author keywords: Surface-molecular imprinting, L-carnitine, methacrylic acid, chiral recognition, Specific adsorption

  Molybdenum periodic table mug  Scientist peptide mug  I shop perodically customisable tote bag


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner