MIPs logo MIPdatabase    HoHoHo MIP2018 Conference website
Custom Search
Reference type: Journal
Authors: Kim HJ, Zhang K, Moore L, Ho D
Article Title: Diamond Nanogel-Embedded Contact Lenses Mediate Lysozyme-Dependent Therapeutic Release.
Publication date: 2014
Journal: ACS Nano
Volume: 8
Issue: (3)
Page numbers: 2998-3005.
DOI: 10.1021/nn5002968

Abstract: Temporarily implanted devices, such as drug-loaded contact lenses, are emerging as the preferred treatment method for ocular diseases like glaucoma. Localizing the delivery of glaucoma drugs, such as timolol maleate (TM), can minimize adverse effects caused by systemic administration. Although eye drops and drug-soaked lenses allow for local treatment, their utility is limited by burst release and a lack of sustained therapeutic delivery. Additionally, wet transportation and storage of drug-soaked lenses result in drug loss due to elution from the lenses. Here we present a nanodiamond (ND)-embedded contact lens capable of lysozyme-triggered release of TM for sustained therapy. We find that ND-embedded lenses composed of enzyme-cleavable polymers allow for controlled and sustained release of TM in the presence of lysozyme. Retention of drug activity is verified in primary human trabecular meshwork cells. These results demonstrate the translational potential of an ND-embedded lens capable of drug sequestration and enzyme activation
Template and target information: timolol maleate
Author keywords: nanomedicine, contact lens, nanodiamond, drug delivery, Biomaterials


  mipdatabase.com logo special offer joke shirt  Lab Hero Periodic tablemug    Shirt featuring the template Lysozyme

Molecules Special Issue call     Sensors Special Issue call






Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:
US listings   UK listings

Searching for Molecular Imprinting books on Amazon.com:
Molecular Imprinting
Imprinted Polymers
Polymer Chemistry
Organic Chemistry
Biosensors

Find what you need at Amazon.com

Lab supplies from Amazon