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Reference type: Journal
Authors: Jiang X, Wu C, Liu Z, Cheng X
Article Title: Preparation and properties of theophylline surface-imprinted polymer microspheres.
Publication date: 2014
Journal: Polymer Materials Science and Engineering
Volume: 30
Issue: (1)
Page numbers: 167-171.

Abstract: Poly (GMA-DVB) microsphere were modified with 4, 4'-azobis(4-cyanopentanoic acid)(ACPA) on the surface. Then the molecular imprinting polymer imprinted with theophylline was grafted to the surface of modified Poly (GMA-DVB) microsphere. The surface-imprinted polymer microsphere was characterized by IR, particle size analysis and scanning electron microscopy (SEM). The adsorption and molecular recognition of theophylline by molecularly imprinted microspheres (MIMs) were measured. The influence of the synthetic conditions on the property of the material was investigated. The experimental results show that the graft ratio of MIMs increases with the increasing of the epoxy content and the reducing of the amount of solvent. MIMs show a high adsorption capacity and good recognition property, and the partition coefficient of the microspheres adsorbing theophylline is 2.81~3.62. The adsorption equilibrium can be achieved within 3 h at room temperature
Template and target information: theophylline
Author keywords: microsphere, molecular recognition, Surface-imprinted polymer, theophylline

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