MIPs logo MIPdatabase     MIP2018 Conference website
Custom Search
Reference type: Journal
Authors: Yola ML, Atar N, Eren T
Article Title: Determination of amikacin in human plasma by molecular imprinted SPR nanosensor.
Publication date: 2014
Journal: Sensors and Actuators B: Chemical
Volume: 198
Page numbers: 70-76.
DOI: 10.1016/j.snb.2014.02.107
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0925400514002925

Abstract: The molecular imprinting technique depends on the molecular recognition. It is polymerization method occuring around the target molecule. Thus this technique creates specific cavities in the cross-linked polymeric matrices. Amikacin (AMIK) is an important aminoglycoside (AG) antibiotic used to treat different types of bacterial infections. In this study, we prepared surface plasmon resonance (SPR) sensor for the determination of AMIK in human plasma. After the modification of gold surface of SPR chip was performed by allyl mercaptane, AMIK-imprinted poly(2-hydroxyethyl methacrylate-methacryloylamidoaspartic acid) [p(HEMA-MAAsp)] film was generated on the allyl mercaptane modified gold surface. The non-modified and imprinted surfaces were characterized by Fourier transform infrared (FTIR) spectroscopy, atomic force microscopy (AFM) and contact angle measurements. The developed method was validated according to the ICH guideline. The linearity range and the detection limit were obtained as 0.01-0.15 μg/mL and 0.0025 μg/mL (4.3 x 10-9 mol/L), respectively. The developed AMIK-imprinted nanosensor was successfully applied to the human plasma samples for the determination of AMIK
Template and target information: amikacin, AMIK
Author keywords: Amikacin, SPR, molecular imprinting, Validation, Nanosensor


  SMI logo drop earrings  Periodic table Prof shirt  Lab Chick script shirt

Molecules Special Issue call     Sensors Special Issue call






Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:
US listings   UK listings

Searching for Molecular Imprinting books on Amazon.com:
Molecular Imprinting
Imprinted Polymers
Polymer Chemistry
Organic Chemistry
Biosensors

Find what you need at Amazon.com

Lab supplies from Amazon