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Reference type: Journal
Authors: Kecili R, Billing J, Nivhede D, Sellergren B, Rees A, Yilmaz E
Article Title: Fast identification of selective resins for removal of genotoxic aminopyridine impurities via screening of molecularly imprinted polymer libraries.
Publication date: 2014
Journal: Journal of Chromatography A
Volume: 1339
Page numbers: 65-72.
DOI: 10.1016/j.chroma.2014.02.073
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0021967314003458

Abstract: This study describes the identification and evaluation of molecularly imprinted polymers (MIPs) for the selective removal of potentially genotoxic aminopyridine impurities from pharmaceuticals. Screening experiments were performed using existing MIP resin libraries to identify resins selective towards those impurities in the presence of model pharmaceutical compounds. A hit resin with a considerable imprinting effect was found in the screening and upon further investigation, the resin was found to show a broad selectivity towards five different aminopyridines in the presence of the two model active pharmaceutical ingredients (APIs) piroxicam and tenoxicam
Template and target information: aminopyridines, genotoxic impurities, 2-Aminopyridine, 3-Aminopyridine, 4-Aminopyridine, 5-Amino-2-methylpyridine, 5-Amino-2-chloropyridine
Author keywords: Active pharmaceutical ingredients, Aminopyridines, Genotoxic impurities, Molecularly imprinted polymers


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