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Reference type: Journal
Authors: Rao RN, Sravan B, Reddy CK, Meena S, Prashamsa J, Spoorthy P
Article Title: Molecularly imprinted polymer-based, solid-phase extraction followed by liquid chromatographic determination of lacosamide in rat plasma.
Publication date: 2014
Journal: Analytical Methods
Volume: 6
Issue: (9)
Page numbers: 3101-3107.
DOI: 10.1039/C3AY42186D

Abstract: A novel sample clean-up technique, water-compatible, molecularly imprinted, solid-phase extraction (MISPE), combined with high-performance liquid chromatography (HPLC), was developed and validated for selective extraction and determination of lacosamide in rat plasma. The molecularly imprinted polymer (MIP) was synthesized using methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker, chloroform as a porogen, and lacosamide as a template. Its efficacy as a selective sorbent in solid-phase extraction of lacosamide and the effects of various porogenic solvents, pH, crosslinker, and amount of monomer were studied and optimized. The recovery was >98% with a detection limit of 0.03 μg mL-1 over a linear range of 0.1-100 μg mL-1
Template and target information: lacosamide


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