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Reference type: Journal
Authors: Queiroz MEC, Melo LP
Article Title: Selective capillary coating materials for in-tube solid-phase microextraction coupled to liquid chromatography to determine drugs and biomarkers in biological samples: A review.
Publication date: 2014
Journal: Analytica Chimica Acta
Volume: 826
Page numbers: 1-11.
DOI: 10.1016/j.aca.2014.03.024
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0003267014003274

Abstract: In-tube solid-phase microextraction (in-tube SPME) coupled with high performance liquid chromatography (HPLC) or liquid chromatography coupled to mass spectrometry (LC-MS) successfully determines drugs or biomarkers in biological samples by direct sample injection or by simple sample treatment. This technique uses a capillary column as extraction device. Several capillaries (wall-coated open tubular, sorbent-packed, porous monolithic rods, or fiber-packed) with unique phases have been developed and evaluated, aiming to improve the efficiency and selectivity of the in-tube SPME-LC technique. This review describes new developments and applications occurred in recent years, and discusses future trends with emphasis on new extraction devices and current technology used for the synthesis of selective sorbents for bioanalysis, such as (i) polypyrrole, (ii) restricted-access materials, (iii) immunosorbents, (iv) molecular imprinting polymers, (v) monolithic polymers, and (vi) bi-functional materials
Template and target information: Review - capillary solid-phase microextraction
Author keywords: In-tube SPME, immunosorbents, molecular imprinting polymers, Restricted-access materials, polypyrrole, Monolithic phase

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