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Reference type: Journal
Authors: Plotka JM, Biziuk M, Morrison C, Namiesnik J
Article Title: Pharmaceutical and forensic drug applications of chiral supercritical fluid chromatography.
Publication date: 2014
Journal: TrAC Trends in Analytical Chemistry
Volume: 56
Page numbers: 74-89.
DOI: 10.1016/j.trac.2013.12.012
Alternative URL: http://www.sciencedirect.com/science/article/pii/S016599361400020X

Abstract: The supercritical fluid is an excellent choice as the chromatographic mobile phase because it allows rapid separation with high efficiency and applications involving enantioresolution are common. Supercritical fluid chromatography (SFC) is increasingly used for analytical, semi-preparative and preparative purification of chiral compounds, including production of enantiomers that are mainly encountered during drug development. SFC can be used as an alternative to HPLC for many drug substances, so it is gaining popularity in the pharmaceutical industry. The main advantages of SFC in separating chiral pharmaceuticals are: high speed, short analysis time, limited environmental impact and high efficiency. The reduction in the use of organic solvents has cost, health, and safety benefits. Due to these advantages, SFC fulfills all the requirements of Green Analytical Chemistry approaches. In this article, we present application of SFC as a tool for chiral separation of pharmaceuticals and drugs of abuse
Template and target information: Review - chiral supercritical fluid chromatography
Author keywords: Chiral drug, Chiral pharmaceutical, chiral selector, chiral separation, chiral stationary phase, Drugs of abuse, enantioseparation, Green analytical chemistry, pharmaceutical analysis, supercritical fluid chromatography


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