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Abstract: Biologically stimuli-responsive hydrogels, "biomolecule-responsive hydrogels", undergo changes in volume in response to a target biomolecule such as glucose, a protein, or DNA. Biomolecule-responsive hydrogels have attracted considerable attention as novel smart biomaterials in the biomedical field because target biomolecules such as saccharides and proteins are useful signals for site-specific drug delivery systems or for monitoring physiological changes. There are several strategies for designing biomolecule-responsive hydrogels, which combine the ability to recognize a target molecule with the ability to induce a structural.change in the hydrogel network. A standard strategy uses the combination of the molecular recognition events of biomolecules such as enzymes, lectins and antibodies with the responsive behavior of pH- or temperature-responsive polymers. We have proposed another strategy that utilizes biomoleoular complexes like lectin-saccharide complexes and antigen-antibody complexes as dynamic crosslinks of hydrogel networks. This article reviews the relevant research of biomolecule-responsive hydrogels that were strategically designed by using the recognition functions of biomolecules such as enzymes, proteins, or DNA.,
Template and target information: Review - responsive hydrogels
Author keywords: hydrogel, Biomolecule, stimuli-responsive hydrogel, molecular recognition, complex, Dynamic Crosslink, Biomolecule-Responsiveness, molecular imprinting, Drug delivery system, Diagnosis System