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Reference type: Journal
Authors: Kamel AH, Galal HR
Article Title: MIP-Based Biomimetic Sensors for Static and Hydrodynamic Potentiometric Transduction of Sitagliptin in Biological Fluids.
Publication date: 2014
Journal: International Journal of Electrochemical Science
Volume: 9
Issue: (8)
Page numbers: 4361-4373.
Alternative URL: http://electrochemsci.org/papers/vol9/90804361.pdf

Abstract: Solid contact potentiometric membrane sensors for sitagliptin (STG) incorporated with molecular imprinted polymer (MIP) were synthesized and implemented. The sensors were fabricated with conventional and tubular configurations with a graphite-based electrical contact, and no internal reference solution. The selective membranes consist of sitagliptin-methacrylic (MIP/MAA) or 2-vinyl pyridine (MIP/2-VP)-ethylene glycol methacrylate (EGDMA) electroactive materials dispersed in a PVC matrix of o-nitrophenyloctyl ether (o-NPOE) plasticizer. The determination of STG was carried out in acidic solution at pH 5, where positively charged species predominated prevalently. The suggested sensors exhibited marked selectivity, sensitivity, long term stability and reproducibility. At their optimum conditions, the sensors displayed wide concentration ranges of 5.0 x 10-6 - 1.0 x 10-2 mol L-1 and 1.0 x 10-5 - 1.0 x 10-2 mol L-1 with slopes of about 52.7-40.5 mV decade-1; respectively. Sensors exhibit detection limits of 2.6 x 10-6 and 5.3 x 10-6 mol L-1 upon the use of MAA and 2-VP monomers in the imprinted polymer, respectively. Validation of the assay method according to the quality assurance standards (range, within-day repeatability, between-day variability, standard deviation, accuracy, and good performance characteristics) which could assure good reliable novel sensors for STG estimation was justified. Application of the proposed flow-through assay method for routine determination of STG in pharmaceutical formulations and biological fluids carried out.
Template and target information: sitagliptin, STG
Author keywords: Molecularly imprinted polymers, Potentiometric sensors, Sitagliptin, Flow injection analysis (FIA), biological fluids


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