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Reference type: Journal
Authors: He H, Zhou LQ, Wang Y, Li CY, Yao J, Zhang W, Zhang QW, Li MY, Li HW, Dong WF
Article Title: Detection of trace microcystin-LR on a 20 MHz QCM sensor coated with in situ self-assembled MIPs.
Publication date: 2015
Journal: Talanta
Volume: 131
Page numbers: 8-13.
DOI: 10.1016/j.talanta.2014.07.071
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0039914014006390

Abstract: A 20 MHz quartz crystal microbalance (QCM) sensor coated with in situ self-assembled molecularly imprinted polymers (MIPs) was presented for the detection of trace microcystin-LR (MC-LR) in drinking water. The sensor performance obtained using the in situ self-assembled MIPs was compared with traditionally synthesized MIPs on 20 MHz and normal 10 MHz QCM chip. The results show that the response increases by more than 60% when using the in situ self-assembly method compared using the traditionally method while the 20 MHz QCM chip provides four-fold higher response than the 10 MHz one. Therefore, the in situ self-assembled MIPs coated on a high frequency QCM chip was used in the sensor performance test to detect MC-LR in tap water. It showed a limit of detection (LOD) of 0.04 nM which is lower than the safety guideline level (1 nM MC-LR) of drinking water in China. The low sensor response to other analogs indicated the high specificity of the sensor to MC-LR. The sensor showed high stability and low signal variation less than 2.58% after regeneration. The lake water sample analysis shows the sensor is possible for practical use. The combination of the higher frequency QCM with the in situ self-assembled MIPs provides a good candidate for the detection of other small molecules
Template and target information: microcystin LR, MC-LR
Author keywords: Molecularly imprinted polymers, In situ self-assembly, quartz crystal microbalance, microcystin-LR, High frequency QCM

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