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Reference type: Journal
Authors: Jha SK, Liu CJ, Hayashi K
Article Title: Molecular imprinted polyacrylic acids based QCM sensor array for recognition of organic acids in body odor.
Publication date: 2014
Journal: Sensors and Actuators B: Chemical
Volume: 204
Page numbers: 74-87.
DOI: 10.1016/j.snb.2014.07.098
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0925400514009381

Abstract: In present research, a novel volatile acids imprinted 3-element quartz crystal microbalance (QCM) sensor array has been designed for the selective recognition of organic acids odor. The target organic acids have been previously assigned as significant biomarker in human body odor and human waste odor. This is also confirmed with solid phase micro-extraction gas chromatography-mass spectrometer (SPME-GC-MS) characterization of body odor samples in present study. Polyacrylic acid (PAA) polymer has been used to prepare three selective molecular imprinted polymers (MIPs). MIP films were coated on the surface of QCM electrodes. Performance of MIP based QCM sensor array has been studied by exposing different concentrations of propenoic acid, hexanoic acid, and octanoic acid in singly and their binary mixtures. The response time and recovery time were 5 s and 14 s, respectively for one of the MIP coated QCM sensor to a typical binary mixture of acids odor. Frequency shift of QCM due to odor molecules adsorption in thin layer of MIP was measured as sensor signal. Sensor signal response matrix has been analyzed with principal component analysis (PCA) and support vector machine (SVM) methods for the odor recognition. The acid odors were identified effectively in principal component (PC) space. SVM classifier results 70-76% recognition rate for three classes of binary odor. While excluding the binary mixture of propenoic acid and octanoic acid the average recognition rate approaches to 95% in 3-fold cross validation of SVM classifier
Template and target information: body odor, volatile organic acids, propenoic acid, hexanoic acid, octanoic acid
Author keywords: Body odor, Organic acid, MIP, QCM, pattern recognition

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