Abstract: Five molecularly imprinted polymer for glibenclamide was prepared by using glibenclamide as the template, acrylamide as the functional monomer and ethyleneglycoldimethacrylate as a cross linker in different ratios. Binding ability analysis showed that acetonitrile pH 4 is the best solvent for rebinding of the analyte. The imprinting factor (IF) was calculated by comparing the retention of glibenclamide on the imprinted polymer with a comparable non-imprinted polymer. The template : monomer : crosslinker ratio of 1:6:70 resulted in an IF of 6.85. This MIP has the potential for use in SPE for purification and concentration of glibenclamide and with further optimization.
Template and target information: glibenclamide
Author keywords: acrylamide, Non covalent polymerization, Glibenclamide, Molecular imprinted solid phase extraction