Authors: Hasanah AN
, Sari TN
, Wijaya N
, Kartasasmita RE
, Ibrahim S
Study of the binding ability of molecular imprinted solid phase extraction for glibenclamide by optimizing template:monomer:crosslinker ratio.
Publication date: 2014
Journal: International Journal of Chemical Science
Alternative URL: http://www.sadgurupublications.com/ContentPaper/2014/9_2071_12%283%292014_IJCS.pdf
Abstract: Five molecularly imprinted polymer for glibenclamide was prepared by using glibenclamide as the template, acrylamide as the functional monomer and ethyleneglycoldimethacrylate as a cross linker in different ratios. Binding ability analysis showed that acetonitrile pH 4 is the best solvent for rebinding of the analyte. The imprinting factor (IF) was calculated by comparing the retention of glibenclamide on the imprinted polymer with a comparable non-imprinted polymer. The template : monomer : crosslinker ratio of 1:6:70 resulted in an IF of 6.85. This MIP has the potential for use in SPE for purification and concentration of glibenclamide and with further optimization.
Template and target information: glibenclamide
Author keywords: acrylamide, Non covalent polymerization, Glibenclamide, Molecular imprinted solid phase extraction
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