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Reference type: Journal
Authors: Sun X, Zhao CY, Wang XH, Huang YP, Liu ZS
Article Title: Thermoresponsive ketoprofen-imprinted monolith prepared in ionic liquid.
Publication date: 2014
Journal: Analytical and Bioanalytical Chemistry
Volume: 406
Issue: (22)
Page numbers: 5359-5367.
DOI: 10.1007/s00216-014-7932-3

Abstract: A thermoresponsive imprinted monolith with the ability of molecular recognition for ketoprofen was prepared for the first time. The smart monolith was synthesized in a stainless steel column using acrylamide (AAm) and 2-acrylamide-2-methyl propanesulfonic acid (AMPS) as functional monomers, which can form interpolymer complexation to restrict access of the analyte to the imprinted networks at low temperatures. To avoid a high back pressure of the column derived from neat dimethyl sulfoxide (DMSO) as a porogenic solvent that is needed to solve polar AMPS, an ionic liquid, [BMIM]BF4, was introduced into the pre-polymerization mixture. The molecular recognition ability towards ketoprofen of the resulting thermoresponsive molecularly imprinted polymer (MIP) monolith displayed significant dependence on temperature compared with a non-imprinted column (NIP), and the greatest imprinting factor was achieved at the transition temperature of 35 C (above 10). Furthermore, the number of binding sites of the smart MIP monolith at 35 C was about 76 times as large as that at 25 -C. In addition, Freundlich analyses indicated that the thermoresponsive MIP monolith had homogeneous affinity sites at both 25 and 35 C with heterogeneity index 0.9251 and 0.9851, respectively
Template and target information: ketoprofen
Author keywords: molecularly imprinted polymer, ketoprofen, monolith, Thermoresponsive, molecular recognition

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